The active ingredients of this product are:
Curcumin C3 Complex® is a standardized extract from turmeric root (Curcuma longa) with a unique composition of curcuminoids (curcumin, demethoxycurcumin and bisdemethoxycurcumin). Curcumin C3 Complex® has been scientifically proven to be a powerful antioxidant preventing formation of free radicals and neutralizing already-formed free radicals, i.e., higher ORAC (Oxygen Radical Absorbance Capacity) value than green tea extract, green coffee extract and grape seed extract). Curcumin C3 Complex® is therefore considered to be a bio-protectant due to its dual activity of prevention and intervention of free radicals. Curcumin C3 Complex® may also relieve temporary joint inflammation and pain that occurs after overexertion during intensive physical activity. From a mode of action point of view, Arachidonic Acid is broken down via two major pathways (Arachidonic Acid Cascades). AA cascade via Cyclooxygenase, or COX pathway, generates inflammation-causing Prostaglandins and Thromboxanes, and AA cascade via Lipoxygenase, or LOX pathway, generates inflammation-causing Leukotrienes. Cyclooxygenase 2 (COX-2) becomes abundant in activated/stimulated macrophages and other cells at sites of inflammation. Curcuminoids naturally inhibit COX and LOX enzymes.
BioPerine® is a patented natural extract from black pepper fruit which improves the absorption and bioavailability of nutrients. The non-specific mechanisms for improving rapid absorption of nutrients may include increased blood supply to the GI tract, increased active nutrient transport by modulating efflux mechanisms (P-glycoprotein inhibition) and inhibition of solubilization by modulating metabolizing enzymes (glucuronidation).